Screening patients cells
to improve drug discovery
ArcoScreen aims at revolutionizing the discovery of drugs targeting G protein coupled receptors (GPCRs). Our technology allows the identification of a drug's mode of action in a single assay, directly on patient cells, which greatly increases the quality and the reliability of the results obtained.
Thanks to the use of a microfluidic chip, our assay is fully automatized and delivers results in only 15 minutes.
5 assays in 1
Suitable for primary cells
Early stage signalisation detection
Library of 250 GPCR expressing cell lines
Results in 15 min
Sample storage at -80°
© Thamani Dahoun and Margaux Duchamp
G Protein Coupled Receptors (GPCRs) represent 35% of all approved modern drug targets and are a major part of the 200 US most profitable drugs. These proteins are the most successful drug targets to treat diseases like cancer, Parkinson’s or Alzheimer’s. Current drug screening assays targeting GPCRs are time consuming and require high investments in liquid handling robots. Current methods need four successive assays to decipher the drug’s mode of action; each one lasts several hours, potentially generates radioactive waste and prevents the use of patient cells (replaced by approximate model cells), thus leading to more challenging clinical trials approval, and impacting the time-to-market of new drugs. Our solution, SynScreen revolutionizes GPCR screening by drastically reducing the assay time from hours to minutes by combining 4 tests in a unique and simple assay.
© Fabien Roy and Yael Sidler
Team & Sponsors
Proud to be part of this innovative project !
Margaux Duchamp, PhD.
CEO & Co-founder
Co-founder and CEO of ArcoScreen. Her expertise lies in microfluidic devices for biological applications. She has also complemented her skill set by attending various entrepreneur trainings.
Thamani Dahoun, PhD.
CTO & Co-founder
Co-founder and CTO of ArcoScreen. Thamani has more than 10 years of expertise in the GPCR screening field and is the inventor of the new GPCR screening method.
Lucas Yerly, MSc.
Lead engineer on the SynScreen technology. Lucas has a previous startup experience working on product development and automation of an instrument combining fluidic and optical elements.